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sparsentan will decrease the extent or outcome of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Watch. Sparsentan (a CYP2C19 inducer) decreases publicity of CYP2C19 substrates and cuts down efficacy connected with these substrates.Modafinil’s suppression of brain CYP2C9 could describe modafinil’s capacity to cut down rea